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Low protein + peptide binding
Helps minimize nonspecific adsorption to preserve valuable proteins and peptides and support stronger product recovery.
Patent-pending membrane technology
Posipep™
High-performance sterile filtration with low protein and peptide binding
Patent-pending, positively charged PES engineered for high throughput, low nonspecific protein and peptide binding, reliable microbial retention, and effective endotoxin reduction.
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Capsules & Syringe
0.03–0.45 µmAvailable pore sizes
>7 logValidated bacterial retention
Single layerPositively charged PES
Capsule + cartridgeScalable formats
Performance without the recovery tradeoff
Low-binding sterile filtration with electrostatic endotoxin capture
Posipep™ combines a hydrophilic PES membrane with a stable positive charge. Its low-binding construction helps minimize nonspecific adsorption of valuable proteins and peptides, while electrostatic attraction captures negatively charged endotoxin and other biological contaminants.
The result is a high-flow filtration platform designed to support strong product recovery, reliable microbial retention, and endotoxin reduction without a separate downstream adsorptive step.
High-performance advantages
Engineered to protect high-value proteins and peptides
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Endotoxin removal
Electropositive membrane sites capture negatively charged endotoxin while absolute-rated pore options provide validated bacterial retention.
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Exceptional flow + throughput
Single-layer hydrophilic PES construction supports efficient processing, strong throughput, and low extractables.
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Scalable hardware
Available in compact capsules and 5–40 inch cartridge configurations for development through production.
Mechanism
Selective capture. Strong recovery.
The membrane’s cationic surface attracts negatively charged endotoxin while its low-binding PES construction helps preserve proteins and peptides. Its absolute-rated pore structure provides validated bacterial retention.
1Fluid enters the hydrophilic PES membrane.
2Pore structure retains microorganisms.
3Positive sites capture endotoxin and cellular debris.
4Filtered fluid exits with reduced endotoxin burden and high product recovery.
Positive membrane sites
Adsorbed endotoxin
Retained microorganisms
Technical specifications
A configurable filtration platform
| Pore size | Primary use | Diffusion test | Minimum bubble point | Format |
|---|---|---|---|---|
| 0.03 µm | Mycoplasma reduction | 60 psig | Diffusion method | Capsule / cartridge |
| 0.10 µm | Enhanced bioburden control | 48 psig | Diffusion method | Capsule / cartridge |
| 0.22 µm | Sterilizing filtration | 35 psig | 50 psig | Capsule / cartridge |
| 0.45 µm | Clarification / endotoxin reduction | 20 psig | 25 psig | Capsule / cartridge |
MembranePositively charged, absolute-rated PES
Support and hardwarePolypropylene · thermally bonded
Maximum forward ΔP80 psid at 20 °C
Autoclave121 °C for 30 minutes · 25+ cycles
Recommended applications
Built for sensitive proteins, peptides, and critical aqueous processes
Process water
Water for Injection
Aqueous buffers
Biopharmaceutical intermediates
Sterile bulk solutions
Endotoxin-sensitive processes
Evaluate Posipep™
Protect recovery while reducing endotoxin
Share your protein or peptide, fluid composition, endotoxin challenge, target reduction, batch volume, and throughput requirements.
*Typical endotoxin reduction depends on influent concentration, flow rate, fluid composition, membrane area, and operating conditions. Protein and peptide recovery is molecule- and process-dependent. Final performance should be confirmed in the intended process. Posipep™ is a working product mark pending formal trademark clearance.
